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Zonisamide Lawsuit


FDA Issues Information on Risk for Metabolic Acidosis


Zonisamide Linked to Metabolic Acidosis

Younger Patients Affected More Severely and More Frequently

Following a review of updated clinical data, The Food and Drug Administration issued information today on the risk for metabolic acidosis in some patients taking the anti-convulsant agent zonisamide (Zonegran).

Zonisamide is indicated as adjunctive therapy in the treatment of partial seizures in adults with epilepsy. Metabolic acidosis is a disturbance in the body's acid-base balance that results in excessive acidity of the blood.

Metabolic acidosis can result in hyperventilation, and non-specific symptoms such as fatigue and anorexia, or more severe symptoms including cardiac arrhythmias or stupor. Chronic metabolic acidosis can have adverse effects on the kidneys and on bones, and can retard growth in children. Patients with predisposing conditions or therapies, including renal disease, severe respiratory disorders, diarrhea, surgery, ketogenic diet, or certain other drugs may be at greater risk for developing metabolic acidosis following treatment with zonisamide. The risk of zonisamide-induced metabolic acidosis appears to be more frequent and severe in younger patients.

FEB-23-09: Zonisamide Linked to Metabolic Acidosis [FDA: ZONISAMIDE CAUSING METABOLIC ACIDOSIS]

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